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Overproduction of this TRA-1A-binding region has germ line, and we speculate that this regulator targets the TRA-2/TRA-1 complex.The intracellular domain of TRA-2A is likely to be produced as a soluble protein in vivo through proteolytic cleavage of TRA-2A or through translation of an germ line-specific m RNA.We further show that tagged derivatives of the intracellular domain of TRA-2 localize to the nucleus, supporting the hypothesis that this domain is capable of modulating TRA-1A activity in a manner reminiscent of Notch and Su(H).Ci and the Gli proteins of vertebrates (Zarkower and Hodgkin 1992). A direct interaction between the intracellular domain of TRA-2A and FEM-3 inhibits the masculinizing activity of the FEM proteins, and although the mechanism of inhibition remains to be determined, this interaction would seem sufficient to explain the feminizing role of TRA-2A (Mehra et al. In support of this idea, overproduction of the intracellular domain of TRA-2A as a soluble protein in the somatic tissues of animals is strongly feminizing (Kuwabara and Kimble 1995; Mehra et al. A 1.8 kb m RNA specific to the hermaphrodite germ line can encode a second TRA-2 protein known as TRA-2B, which is equivalent to the intracellular domain of TRA-2A (Okkema and Kimble 1991; Kuwabara et al. Genetic evidence suggests that TRA-2B may limit the extent of spermatogenesis in the hermaphrodite.The FEM proteins then inhibit the activity of TRA-1A to cause male development. The , encodes an atypical calpain protease (Barnes and Hodgkin 1996).When the two proteins are expressed together in insect cells, TRA-3 can cleave TRA-2A to release a fragment that includes part of the intracellular domain of TRA-2A (Sokol and Kuwabara 2000).
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At the autopsy of the Bunker twins, one of the anatomists opined that their active sex lives "shocked the moral sense of the community" -- even though the truth is that the Bunkers' neighbors appeared to have just accepted the situation.
A little known fact is that the Bunker wives' father originally objected to his daughters marrying the twins because they were conjoined, but because they were Asian.
Typically, people who are close to conjoined twins come to adjust and see them as different but normal; they seem fairly untroubled by the idea of conjoined twins pursuing sex and romance. The best example of this would probably be the story of Chang and Eng Bunker, "the Siamese Twins," so called because they were from Siam (now Thailand).
Chang and Eng were joined by just a bit of liver and some skin.